Profile: Prof Dmitri Sviridov
Contact Prof Dmitri Sviridov
Direct: +61 3 8532 1363
Fax: +61 3 8532 1100
Email Prof Dmitri Sviridov
Education
| Title | Institute | Year |
| Associate Professor | School of Medicine and Pharmacology, University of Western Australia | 2008 |
| Fellow | American Heart Association | 2004 |
| Senior Research Fellow (equivalent to Associate Professor) | National Cardiology Research Centre, Moscow, USSR | 1990 |
| Ph. D. (Biomedical Science) | National Cardiology Research Centre, Moscow, USSR | 1982 |
| MD & B. Sc. (Medical Biochemistry) | Second Moscow Medical School, Moscow, USSR | 1978 |
Memberships
| Institute | Year |
| International Atherosclerosis Society | Member from 1985 |
| Australian Atherosclerosis Society | Member from 1993 |
| American Heart Association | Member from 1995 |
| The Australian Society for Medical Research | Member from 1998 |
| National Association of Research Fellows | Member from 1999 |
| Australian Atherosclerosis Society | Director 2002 – 2006 |
| American Society for Biochemistry and Molecular Biology | Member from 2003 |
| American Heart Association and the Council of Arteriosclerosis, Thrombosis and Vascular Biology | Fellow from 2004 |
| Australian Vascular Biology Society | Member from 2007 |
Fellowship
| Title | Institute | Year |
| NH&MRC Senior Research Fellow | Baker IDI | 1999 – present |
Research interests
The lipoproteins and atherosclerosis laboratory is investigating the body’s natural protective mechanism process which removes excess cholesterol from the vessel wall. This mechanism is dependent on two functions, the cells ability to transfer excess cholesterol to the plasma, and the plasma’s capacity to receive excess cholesterol from the cells. Understanding how these functions work, why and how the protective mechanism process breaks down and how to supplement this mechanisms if its activity is insufficient will assist in the development of therapeutics which will restore this process in patients where it is impaired or no longer working.
Publications
Endothelial cell culture on fibrillar collagen: a model to study platelet adhesion and liposome targeting to intracellular collagen matrix. Proc. Natl. Acad. Sci. USA, (1981), v. 78, p. 5603 5607. Chazov, E.I., Alexeev, A.V., Antonov, A.S., Koteliansky, V.E., Leytin, V.L., Lyubimova, E.V., Repin, V.S., Sviridov, D. D., Torchilin, V.P., Smirnov, V.N.
Carrier directed targeting of liposomes and erytrocytes to denuded areas of vessel wall. Proc. Natl. Acad. Sci. USA (1986), v.83, p. 6603 6607. Smirnov, V.N., Domogadsky, S.P., Dolgov, V.V., Hvatov, V.B., Klibanov, A.L., Koteliansky, V.E., Muzykantov, V.R., Repin, V.S., Samokhin, G.P., Shekhonin, B.V., Smirnov, M.D., Sviridov, D. D., Torchilin. V.P., Chazov, E.I.
Ontogenic regulation of apolipoprotein B messenger RNA editing during human and rat development in vivo. Arterioscler. Thromb. (1992), v.12, p. 468 473. Patterson, A. P., Tennison, G.E., Hoeg, J. M., Sviridov, D. D., Brewer, H.B.
Identification of a sequence of apolipoprotein A-I associated with the efflux of intracellular cholesterol to human serum and apolipoprotein A-I containing particles. Biochemistry (1996) v. 35, p. 189-196. Sviridov, D., Pyle, L., Fidge, N.
Efflux of cellular cholesterol and phospholipid to apolipoprotein A-I mutants. J. Biol. Chem. (1996) v. 271, p. 33277-33283. Sviridov, D., Pyle, L., Fidge, N.
Deletion of the pro-peptide of apolipoprotein A-I reduces protein expression, but stimulates effective conversion of pre-HDL to -HDL. J. Lipid. Res. (2000) v. 41, 1872-1882. (IF=4.1) Sviridov, D., Pyle, L., Jauhiainen, M., Ehnholm, C., Fidge, N.
Identification of a sequence of apolipoprotein A-I associated with the activation of lecithin:cholesterol acyltransferase. J. Biol. Chem. (2000) v. 275, 19707-19712. (IF=7.3) Sviridov, D., Hoang, A., Sawyer, W., Fidge, N.
Apolipoprotein A-I stimulates transport of intracellular cholesterol to cell surface caveolae. Biochem. J. (2001) v.358, p. 79-86. (IF=4.3) Sviridov, D., Fidge, N., Beaumer-Gallon, G. Fielding, C.
Dynamics of reverse cholesterol transport; protection against atherosclerosis. Atherosclerosis (2002), v.161, p. 245-254. (IF=3.5) Sviridov, D., Nestel, P.
Delineation of the role of pre1-HDL in cholesterol efflux using isolated pre1-HDL. Arterioscler. Throm. Vasc. Biol. (2002) v.22, p. 1482-1488. (IF=5.8) Sviridov, D., Miyazaki, O., Theodore, K., Hoang, A., Fukamachi, I., Nestel, P.
Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux. J. Biol. Chem. (2003), v. 278, p. 11015-11019. (IF=7.3) Escher, G., Croft, K., Krozowski, Z., Sviridov, D.
Physical fitness and reverse cholesterol transport. Arterioscler. Thromb. Vasc. Biol. (2004), v. 24, p. 1087-1091. (IF=7.1) Olchawa, B., Kingwell, B. A., Hoang, A., Schneider, L., Miyazaki, O., Nestel, P., Sviridov, D.
Expression of caveolin-1 enhances cholesterol efflux in hepatic cells. J. Biol. Chem. (2004), v. 279, p.14140-14146. (IF=6.7) Fu, Y., Hoang, A, Escher, G., Parton, R., Krozowski, Z., Sviridov, D.
Human Immunodeficiency Virus Impairs Reverse Cholesterol Transport from Macrophages. PLoS Biology (2006), v. 4, p. e365. (IF=14.8) Mujawar, Z., Rose, H., Morrow, M. P., Pushkarsky, T., Dubrovsky, L., Mukhamedova, N., Dart, A., Fu, Y., Orenstein, J. M., Bobryshev, Y. V., Bukrinsky, M., Sviridov, D.
HIV and cardiovascular disease: contribution of HIV-infected macrophages to development of atherosclerosis. PLoS Medicine (2007) v. 4, p. e43. (IF=13.8) Bukrinsky, M., Sviridov, D.
Advanced Glycation of Apolipoprotein A-I Impairs Its Antiatherogenic Properties. Diabetologia (2007) v. 50, p. 1770-1779. (IF=5.3) Hoang, A., Murphy, A., Coughlan, M., Thomas, M., Forbes, J.M., O’Brien, R.,. Cooper, M. E., Chin-Dusting J., Sviridov, D.
The Role of Different Regions of ABCA1 in Cholesterol Efflux. Biochemistry (2007) v. 46, p. 9388-9398. (IF=3.6) Mukhamedova, N., Fu, Y., Bukrinsky, M., Remaley, A., Sviridov, D.
The Effect of CETP overexpression and inhibition on Reverse Cholesterol Transport. Cardiovasc. Res. (2008) v. 77, p. 732-739. Tchoua, U., D’Souza, W., Mukhamedova, N., Blum,D., Niesor, E., Mizrahi, J., Maugeais, C., Sviridov, D.
High density lipoprotein reduces the human monocyte inflammatory response. Arterioscler. Thromb. Vasc. Biol (2008) (in press). Murphy, A. J., Woollard, K. J., Hoang, A, Mukhamedova, N., Stirzaker, R. A., McCormick S. P. A., Remaley, A. T., Sviridov, D. Chin-Dusting, J.
