Diabetic Complications

Professor Karin Jandeleit-Dahm
Head, Diabetes and Kidney Disease
karin.jandeleit-dahm@bakeridi.edu.au

Laboratory Research Overview

The Diabetes and Kidney Disease Laboratory investigates the metabolic and hemodynamic pathways leading to diabetes related vascular complications specifically kidney disease and atherosclerosis. The research focuses common pathways in the kidney and macrovasculature and how both disease entities influence each other. The ultimate goal is to identify new targets to prevent and better treat diabetic complications to reduce the burden of disease in diabetic patients.

Research Focus

• Vasoactive hormones in diabetic micro- and macrovascular disease
• Oxidative stress
• The AGE/RAGE pathways
• Novel treatments to treat diabetic complications
• Clinical translation of treatments for diabetic complications

Research Projects

The role of the receptor RAGE in diabetes associated atherosclerosis

Group leader: Dr Anna Watson

In this project we investigate the role of advanced glycation end products and the interaction with the receptor RAGE in diabetes associated kidney disease and atherosclerosis.

The role of oxidative stress in diabetes associated renal disease and atherosclerosis

Group leader: Dr Stephen Gray

In this project we investigate the role of oxidative stress and specifically the role of NOX isoforms in diabetes associated kidney disease and atherosclerosis.

The role of Methylglyoxal in diabetes associated atherosclerosis

Group leader: Prof Karin Jandeleit-Dahm/Assoc Prof Merlin Thomas

In this project we investigate the role of MGO in the development of atherosclerosis using animal models and in vitro experiments.

Lab Head Profile

Prof Karin Jandeleit-Dahm is a clinician scientist and Co- Head of the Division Clinical and Pre-clinical Diabetes at Baker IDI Heart and Diabetes Institute.

She is a NHMRC Senior Research Fellow and has a clinical appointment at The Alfred Hospital. Furthermore, she is Professor in the Department of Medicine, Monash University and Professor of Medicine at the University of Hannover, Germany.

Prof Jandeleit-Dahm's major research focus is the pathogenesis and interactions of cardiovascular and renal disease in diabetes with a particular focus on the AGE/RAGE axis in diabetic vascular complications.

Achievements/Awards

• Professor of Medicine (Adjunct), Monash University
• Professor Medicine, University of Hannover, Germany
• NHMRC Senior Research Fellow
• Director, Australian Atherosclerosis Society, President Elect 2011-2014
• Associate Editor, Diabetologica

Publication Highlights

• Candido R, Allen TJ, Lassila M, Cao Z, Thallas V, Cooper ME, Jandeleit-Dahm KA. Irbesartan but not amlodipine attenuates diabetes-associated atherosclerosis. Circulation 2004;109:1536-42.
• Lassila M, Seah KK, Allen TJ, Thallas V, Thomas MC, Candido R, Burns WC, Forbes JM, Calkin AC, Cooper ME, Jandeleit-Dahm KA. Accelerated nephropathy in diabetic apoE lipoprotein knockout mice- role of advanced glycation end products. Journal of the American Society of Nephrology 2004;15:2125-38.
• Jandeleit-Dahm KA, Tikellis C, Reid CM, Johnston CI, Cooper ME. Why blockade of the RAS reduces the incidence of diabetes. Journal of Hypertension 2004;15(8):2125-2138.
• Soro-Paavonen A, Watson AM, Li J, Paavonen K, Koitka A, Calkin AC, Barit D, Coughlan MT, Drew BG, Lancaster GI, Thomas M, Forbes JM, Nawroth PP, Bierhaus A, Cooper ME, Jandeleit-Dahm KA. RAGE deficiency attenuates the development of atherosclerosis in diabetes. Diabetes 2008;57:2461-9.
• Kleinschnitz C, Grund H, Wingler K, Armitage ME, Jones E, Mittal M, Barit D, Schwarz T, Geis C, Kraft P, Barthel K, Schuhmann MK, Herrmann AM, Meuth SG, Stoll G, Meurer S, Schrewe A, Becker L, Gailus-Durner V, Fuchs H, Klopstock T, de Angelis MH, Jandeleit-Dahm K, Shah AM, Weissmann N, Schmidt HH. Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLOS Biology 2010;8(9):pii: e1000479.

Key Staff

Contact

Direct: +613 8532 1739
Email: karin.jandeleit-dahm@bakeridi.edu.au